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T-cell lymphoma in the CNS: clinical and pathologic features
S Morgello1, K Maiese, C K Petito
1Department of Pathology (Neuropathology), New York Hospital-Cornell University Medical College, New York.
Neurology
|September 1, 1989
Summary
Central nervous system (CNS) T-cell lymphoma presents diverse clinical and pathologic features. Neurologic symptoms can be the initial sign of primary or secondary CNS T-cell lymphoma.
Area of Science:
- Neurology
- Oncology
- Pathology
Background:
- T-cell lymphoma can manifest as primary or secondary neoplasms within the central nervous system (CNS).
- Understanding the diverse presentations of CNS T-cell lymphoma is crucial for timely diagnosis and management.
Observation:
- This report details 8 patients with primary or secondary CNS T-cell malignancies.
- Five patients exhibited neurological symptoms including seizures, visual impairment, cranial nerve palsies, motor/sensory deficits, gait ataxia, and paraparesis.
- Three patients were asymptomatic but had leptomeningeal tumor and parenchymal infiltration upon postmortem examination.
Findings:
- Histological analysis revealed 4 large cell, 3 mixed large and small cell, and 1 unclassified T-cell lymphoma.
- Primary parenchymal CNS lymphoma occurred in 3 patients, while 2 had epidural lymphoma originating from adjacent bone marrow.
- Neurologic abnormalities can be the initial presenting signs of CNS T-cell lymphoma.
Implications:
- The clinical and pathological manifestations of T-cell lymphoma in the CNS are varied.
- Recognizing diverse neurological signs is key for identifying CNS T-cell lymphoma, whether primary or secondary.
- This highlights the importance of considering CNS involvement in T-cell lymphoma patients presenting with neurological deficits.