Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

3.5K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
3.5K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.2K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.2K
Adult Stem Cells01:33

Adult Stem Cells

34.0K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
34.0K
Stem Cell Culture01:17

Stem Cell Culture

6.4K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.4K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.8K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.3K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intestinal CD4<sup>-</sup>CD8αβ<sup>-</sup>TCRαβ<sup>+</sup> T cells function as tolerogenic antigen presenting cells in mice.

Nature communications·2025
Same author

RNA Virome Analysis of Haemaphysalis longicornis Ticks Collected in Hyogo, Japan.

Japanese journal of infectious diseases·2025
Same author

<i>COI</i> barcoding can distinguish bisexual and parthenogenetic populations of <i>Haemaphysalis longicornis</i> in Japan: Revisiting methods with SNP analysis as another possible method.

International journal for parasitology. Parasites and wildlife·2025
Same author

Bile acid-FXR signaling facilitates the long-term maintenance of hepatic characteristics in human iPSC-derived organoids.

Cell reports·2025
Same author

Discovery and Theoretical Studies of Nonenzymatic Polyketide Dimerizations of Chaetophenols.

Organic letters·2025
Same author

Inadequate Efficacy of Biologics for Treating Proximal Ileal Lesions in Crohn's Disease: A Prospective Multicenter Study.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2024
Same journal

Comment on "Dependence-related screening positivity among regular stimulant-laxative users with chronic constipation: a multicenter prospective observational study".

Journal of gastroenterology·2026
Same journal

Comment on "Dependence-related screening positivity among regular stimulant-laxative users with chronic constipation: a multicenter prospective observational study".

Journal of gastroenterology·2026
Same journal

METTL3/FTO drives ferroptosis in colorectal cancer by targeting m<sup>6</sup>A modification of MUC1 mRNA and YTHDF2-dependent SLC7A11/GSH pathway.

Journal of gastroenterology·2026
Same journal

Risk of lymph-node metastasis in early onset T1 colorectal cancer: a systematic review and meta-analysis.

Journal of gastroenterology·2026
Same journal

Clinical characteristics of acute pancreatitis in patients with inflammatory bowel disease: a nationwide survey in Japan.

Journal of gastroenterology·2026
Same journal

Rethinking proton pump inhibitor deprescribing: from tapering strategies to patient-centered management.

Journal of gastroenterology·2026
See all related articles

Related Experiment Video

Updated: Mar 11, 2026

Planarian Immobilization, Partial Irradiation, and Tissue Transplantation
10:09

Planarian Immobilization, Partial Irradiation, and Tissue Transplantation

Published on: August 6, 2012

20.2K

Intestinal stem cell transplantation.

Tetsuya Nakamura1, Mamoru Watanabe2

  • 1Department of Advanced Therapeutics for GI Diseases, Tokyo Medical and Dental University, Tokyo, 113-8519, Japan. nakamura.gast@tmd.ac.jp.

Journal of Gastroenterology
|November 27, 2016
PubMed
Summary
This summary is machine-generated.

Intestinal organoid technology allows for the expansion of intestinal epithelial cells. These expanded cells can be transplanted to regenerate intestinal tissues, offering potential for research and treating intestinal diseases.

Keywords:
Intestinal stem cellOrganoid technologyRegenerative medicineTransplantation

More Related Videos

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases
07:45

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Published on: September 1, 2017

12.8K
Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing
05:27

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing

Published on: January 26, 2024

1.7K

Related Experiment Videos

Last Updated: Mar 11, 2026

Planarian Immobilization, Partial Irradiation, and Tissue Transplantation
10:09

Planarian Immobilization, Partial Irradiation, and Tissue Transplantation

Published on: August 6, 2012

20.2K
Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases
07:45

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Published on: September 1, 2017

12.8K
Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing
05:27

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing

Published on: January 26, 2024

1.7K

Area of Science:

  • Gastroenterology and Regenerative Medicine

Background:

  • Organoid technology enables expansion of intestinal epithelial cells for research.
  • Transplantation of cultured intestinal epithelial cells is a key application.

Purpose of the Study:

  • To review studies on generating new intestinal epithelial tissues via organoid transplantation in mice.
  • To discuss applications in basic intestinal research and regenerative medicine for human diseases.

Main Methods:

  • Overview of successful organoid transplantation studies in mice.
  • Analysis of generated epithelial tissues on native intestinal surfaces.

Main Results:

  • Successful generation of new epithelial tissues in mouse intestines through organoid transplantation.
  • Demonstration of organoid systems' potential for in vivo tissue regeneration.

Conclusions:

  • Organoid transplantation is a viable method for regenerating intestinal epithelium.
  • This approach holds promise for advancing intestinal biology research and developing therapies for intestinal diseases.