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Updated: Mar 11, 2026
Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
Published on: November 8, 2012
Segmented simultaneous multi-slice diffusion weighted imaging with generalized trajectories
Michael Herbst1,2, Weiran Deng1, Thomas Ernst1
1Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
Purpose:
The purpose of this work is to develop and evaluate a single framework for the use of Cartesian and non-Cartesian segmented trajectories for rapid and robust simultaneous multislice (SMS) diffusion weighted imaging (DWI) at 3 Telsa (T).
Methods:
A generalized SMS approach with intrinsic phase navigation using Multiplexed Sensitivity Encoding (MUSE) was developed. Segmented blipped-controlled aliasing in parallel imaging echo planar imaging (EPI) and z-gradient modulated spiral trajectories were examined using SMS DWI scans at 3T with a 32-channel head coil.
Results:
The generalized SMS MUSE reconstruction framework was successful in significantly reducing artifacts for all trajectories. A DWI brain volume with a 67.5-mm height, 1.5-mm isotropic resolution, and 90 diffusion weightings was obtained in a scan time of 6 minutes.
Conclusion:
The MUSE technique can be generalized to allow for reconstruction of both Cartesian and non-Cartesian segmented trajectories. Magn Reson Med 78:1476-1481, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
