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LncRNAs: the bridge linking RNA and colorectal cancer

Yanfei Yang1, Linjie Zhao1, Lingzi Lei1

  • 1Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second Hospital and State Key Laboratory of Biotherapy/Collaborative Innovation Center, West China Hospital, Sichuan University, Chengdu, P. R. China.

Oncotarget
|November 27, 2016
PubMed

Insights

Long noncoding RNAs (lncRNAs) play crucial roles in colorectal cancer (CRC) development and progression. Understanding lncRNA functions offers potential for novel CRC diagnostics and therapeutics.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long noncoding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that do not code for proteins.
  • lncRNAs are increasingly recognized for their regulatory roles in gene expression and cellular processes.
  • Dysregulation of lncRNAs is implicated in various human diseases, including cancer.

Purpose of the Study:

  • To review the multifaceted roles of lncRNAs in colorectal cancer (CRC).
  • To discuss the implications of lncRNA dysregulation in CRC phenotypes such as proliferation, angiogenesis, metastasis, invasion, apoptosis, stemness, and genome instability.
  • To explore the potential clinical applications of lncRNAs in CRC diagnosis and treatment.

Main Methods:

  • Literature review of recent studies on lncRNAs in CRC.
  • Analysis of lncRNA functions and their interactions with cellular molecules (DNA, protein, RNA).
  • Synthesis of information regarding the impact of lncRNAs on CRC progression and clinical outcomes.

Main Results:

  • lncRNAs are significantly dysregulated in CRC and influence key cancer hallmarks.
  • Specific lncRNAs have been identified that promote or suppress CRC cell proliferation, angiogenesis, metastasis, invasion, apoptosis, stemness, and genome instability.
  • lncRNA expression patterns correlate with clinical outcomes in CRC patients.

Conclusions:

  • lncRNAs are critical regulators of colorectal cancer progression.
  • Targeting lncRNAs presents a promising avenue for developing novel therapeutic strategies for CRC.
  • Further research into lncRNA functions can lead to improved diagnostic and prognostic tools for CRC.
Keywords:
angiogenesiscolorectal cancerlncRNAsmetastasisproliferation

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