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Refractory Chronic Rhinosinusitis with Nasal Polyposis.

Benjamin P Hull¹, Rakesh K Chandra¹

¹Department of Otolaryngology-Head & Neck Surgery, Vanderbilt University, 1215 21st Ave S, 7209 MCE-S, Nashville, TN 37232-8605, USA.

Otolaryngologic Clinics of North America

|November 28, 2016

Summary

Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a complex condition with diverse causes, including allergies and innate immunity. Effective management involves surgery, steroids, and long-term patient monitoring for polyp recurrence.

Keywords:

Allergic fungal sinusitis Allergy Asthma Cystic fibrosis Innate immunity Polyps Superantigen

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Area of Science:

Otolaryngology
Immunology
Allergy

Background:

Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a distinct subtype of chronic sinusitis.
CRSwNP etiology is multifactorial, involving allergies, asthma, cystic fibrosis, and innate immune responses.

Purpose of the Study:

To review current literature on the causes and management of CRSwNP.
To highlight the roles of innate immunity and superantigens in CRSwNP pathogenesis.
To emphasize the importance of individualized treatment and long-term follow-up.

Main Methods:

Literature review of recent scientific publications on CRSwNP.
Analysis of etiological factors, including allergic and immunological mechanisms.
Evaluation of current therapeutic strategies and outcomes.

Main Results:

CRSwNP has varied triggers, with allergies and asthma being common.
Innate immunity and superantigens are increasingly recognized as significant factors.
Recurrence of nasal polyps is frequent, necessitating ongoing patient care.

Conclusions:

CRSwNP management requires a multidisciplinary approach.
Endoscopic sinus surgery combined with tailored medical therapy (steroids) is crucial.
Long-term surveillance is essential for managing recurrent nasal polyposis.