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Metastatic Anal Cancer and Novel Agents

Van Morris1, Cathy Eng1

  • 1Department of Gastrointestinal Medical Oncology, The University of Texas - MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 426, Houston, TX 77030, USA.

Surgical Oncology Clinics of North America
|November 28, 2016
PubMed

Insights

Squamous cell carcinoma of the anal canal (SCCA) is rare. While human papilloma virus is linked to SCCA, immune checkpoint inhibitors show promise for metastatic disease, offering new hope for patients.

Area of Science:

  • Oncology
  • Virology

Background:

  • Squamous cell carcinoma of the anal canal (SCCA) is an orphan disease.
  • Human papilloma virus (HPV) infection is associated with SCCA development.
  • Current knowledge has not yielded effective therapies for metastatic SCCA.

Purpose of the Study:

  • To review the efficacy of current and emerging therapies for metastatic SCCA.
  • To highlight the potential of immune checkpoint blockade agents.

Main Methods:

  • Review of existing literature on SCCA treatment.
  • Analysis of clinical trial data for chemotherapy and immunotherapy.

Main Results:

  • Combination chemotherapy with traditional cytotoxic agents has shown efficacy in small studies.
  • Immune checkpoint blockade agents have demonstrated effectiveness in patients with refractory metastatic SCCA.

Conclusions:

  • Immune checkpoint blockade agents represent a promising future treatment for metastatic SCCA.
  • Oncologists should consider clinical trials for managing patients with metastatic SCCA.
Keywords:
Anal cancerChemotherapyHPVImmunotherapyPD-1Squamous cell

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