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Updated: Mar 11, 2026
Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
Published on: October 28, 2022
Prognostic Value of Resistive Index in Neonates with Hypoxic Ischemic Encephalopathy
A Senthil Kumar1, Aparna Chandrasekaran, Rajamannar Asokan
1Department of Neonatology, CHILDS Trust Medical Research Foundation and Kanchi Kamakoti CHILDS Trust Hospital, and *Department of Radiology, Kilpauk Medical College; Chennai, Tamil Nadu, India. Correspondence to: Dr Aparna Chandrasekaran, Department of Neonatology, CHILDS Trust Medical Research Foundation and Kanchi Kamakoti CHILDS Trust Hospital, Nungambakkam, Chennai 600 034, Tamil Nadu, India. appubanu@gmail.com.
Objective:
To evaluate the role of Resistive index measured by cranial doppler ultrasonography in predicting the risk of death/ abnormal neurodevelopmental outcomes in term neonates with hypoxic ischemic encephalopathy.
Methods:
We enrolled 50 term asphyxiated neonates with hypoxic ischemic encephalopathy and measured resistive index within 72 hours from the anterior cerebral artery. Participants underwent tone and developmental assessment at 6-12 months.
Results:
Among the 50 neonates, 25 (50%) had abnormal resistive index (<0.56 or >0.80). Presence of abnormal resistive index increased the risk of death/ abnormal neurological outcomes at 6-12 months [RR (95% CI): 7.5 (2.0,8.6), P<0.01].
Conclusion:
An abnormal resistive index is associated with death/ neurodevelopmental impairment in neonatal hypoxic ischemic encephalopathy.
