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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Fluid Supplementation versus No Fluid Supplementation in Late Preterm and Term Neonates with Asymptomatic

Mangalabharathi Sundaram1, Sourabh Dutta, Anil Narang

  • 1Division of Neonatology, Department of Pediatrics, PGIMER, Chandigarh, India. Correspondence to: Dr Mangalabharathi Sundaram, Division of Neonatology, Departments of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. drmangalabharathi@gmail.com.

Indian Pediatrics
|November 28, 2016
PubMed

Insights

Supplemental intravenous fluids did not show clinical benefit in asymptomatic polycythemic neonates. This study found no significant difference in the need for partial exchange transfusion between groups receiving IV fluids and those receiving routine care.

Area of Science:

  • Neonatal Medicine
  • Pediatric Hematology

Background:

  • Polycythemia (elevated red blood cell count) is common in late preterm and term neonates.
  • Asymptomatic polycythemia can pose risks if not managed appropriately.

Purpose of the Study:

  • To evaluate the efficacy of supplemental intravenous fluids in managing asymptomatic polycythemia in neonates.
  • To compare outcomes between neonates receiving IV fluid supplementation and those receiving routine care.

Main Methods:

  • A randomized controlled trial involving 55 neonates with venous hematocrit between 65-75%.
  • Infants were assigned to receive either 25 mL/kg IV normal saline or routine fluids for 48 hours.

Main Results:

  • No significant difference in the need for partial exchange transfusion between the IV fluid supplementation group (22.2%) and the control group (28.6%).
  • The P-value for this comparison was 0.59, indicating no statistically significant difference.

Conclusions:

  • Supplemental intravenous fluid administration did not demonstrate clinical benefit for asymptomatic polycythemia in this cohort.
  • Current evidence does not support routine IV fluid supplementation for managing asymptomatic neonatal polycythemia (PCV 65-75).
Abstract

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