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Vitamin D Receptor TaqI Gene Polymorphism and Dental Caries in Czech Children
Lydie Izakovicova Holla1, Petra Borilova Linhartova, Jakub Kastovsky
1Clinic of Stomatology, Institutions Shared with St. Anne's Faculty Hospital, Masaryk University, Brno, Czech Republic.
Aim:
We analyzed the VDR TaqI (rs731236) gene polymorphism in children with and those without dental caries.
Methods:
A total of 388 subjects, 153 caries-free (with decayed/missing/filled teeth [DMFT] = 0) and 235 children with dental caries (DMFT ≥1), were genotyped by the TaqMan method.
Results:
Although no significant differences in VDR TaqI allele and genotype frequencies between caries-free and caries-affected children were detected, a significant association between this polymorphism and gingivitis was found (p < 0.05).
Conclusions:
In contrast to previous studies from China and Turkey, the VDR TaqI gene variant cannot be used as a marker for identification of Czech children with increased dental caries risk.
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