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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

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Interprofessional Medication Management in Patients With Multiple Morbidities.

Juliane Köberlein-Neu¹, Hugo Mennemann, Stefanie Hamacher

¹Center for Health Economics and Health Services Research, Schumpeter School of Business and Economics, University of Wuppertal; Department of Social Work, M¨nster University of Applied Sciences; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; Department of Pharmaceutical and Medicinal Chemistry, University of M¨nster; Clinical Pharmacy, Institute of Pharmacy, University of Bonn, Bonn, Germany.

Deutsches Arzteblatt International

|November 29, 2016

Summary

Interprofessional medication management significantly improved pharmacotherapy quality and reduced drug-related problems in multimorbid patients. This collaborative approach enhances medication safety by considering patients

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Area of Science:

Gerontology
Pharmacotherapy
Patient Safety

Background:

Medication reviews and management are crucial for global medication safety.
These practices have evolved from pharmaceutical care activities to interdisciplinary approaches.
This study investigates interprofessional medication management for multimorbid patients, integrating medical conditions and living situations.

Purpose of the Study:

To evaluate the efficacy of an interprofessional medication management strategy.
To assess the impact on pharmacotherapy quality and drug-related problems in multimorbid patients.

Main Methods:

A comprehensive medication management process was implemented.
A 15-month cluster-randomized controlled trial with a stepped wedge design was employed.
The primary endpoint was pharmacotherapy quality, measured by the Medication Appropriateness Index (MAI).

Main Results:

142 patients were included in the intention-to-treat analysis (mean age 76.8 years).
The mean total MAI score significantly decreased from 29.21 to 22.27 (p ≤ 0.001).
A significant reduction in drug-related problems was observed.

Conclusions:

Interprofessional collaboration demonstrably enhances medication safety.
Multidisciplinary teamwork effectively reduces drug-related problems.
This approach addresses aspects beyond the scope of primary care physicians.