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Polymyositis/dermatomyositis associated with dermatitis herpetiformis.
A E Kalovidouris1, F W Miller, T J Lawley
1Rheumatology Division, Indiana University School of Medicine, Indianapolis.
Arthritis and Rheumatism
|September 1, 1989
Summary
Two dermatitis herpetiformis patients developed polymyositis/dermatomyositis, suggesting a shared autoimmune basis and genetic link. This indicates myositis may be more prevalent in dermatitis herpetiformis patients.
Area of Science:
- Immunodermatology
- Rheumatology
- Autoimmune Diseases
Background:
- Dermatitis herpetiformis is a chronic autoimmune blistering skin condition.
- Polymyositis/dermatomyositis are rare autoimmune disorders causing muscle inflammation.
Observation:
- Two patients with dermatitis herpetiformis were observed to develop polymyositis/dermatomyositis.
- Both patients were HLA-B8, DR3 positive.
Findings:
- The co-occurrence of these autoimmune diseases suggests a common immunogenetic predisposition.
- HLA-B8, DR3 positivity was noted in both affected individuals.
Implications:
- This finding supports the role of autoimmunity in the pathogenesis of both conditions.
- It suggests a potential increased risk of myositis in patients diagnosed with dermatitis herpetiformis.