Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

600
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
600
Drug Discovery: Overview01:26

Drug Discovery: Overview

12.6K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
12.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Mycobacterial cyt-<i>bc</i><sub>1</sub><i>:aac<sub>3</sub></i> Oxidase as a Drug Target: Activities of Arylvinylpiperazine Amides and Aminoquinazolines against <i>Mycobacterium ulcerans</i>.

Journal of medicinal chemistry·2026
Same author

An atlas of microtubule lattice parameters regulated through ligand binding to the microtubule-stabilizing sites.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Illuminating chromaffin granules: compartmentalization of endocannabinoids in bovine adrenal glands supports role in hormone modulation.

Biochemical pharmacology·2026
Same author

Studies toward the Total Synthesis of Griseoviridin.

Organic letters·2026
Same author

Synthesis and Early Assessment of Epothilone-Derived Fluorescent Probes for Microtubule Imaging.

ChemMedChem·2026
Same author

Optimizing the Antibiotic Potency and Metabolic Stability of Pyridomycin Using a Semisynthetic Approach.

Journal of medicinal chemistry·2026

Related Experiment Video

Updated: Mar 11, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

9.2K

Recent developments in natural product-based drug discovery for tuberculosis.

Maryline Dong1, Bernhard Pfeiffer1, Karl-Heinz Altmann1

  • 1ETH Zürich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Vladimir-Prelog-Weg 4, HCI H 405, CH-8093 Zürich, Switzerland.

Drug Discovery Today
|November 29, 2016
PubMed
Summary

Natural products offer new hope for tuberculosis treatment. Recent discoveries of novel natural products and analogs show promising activity against Mycobacterium tuberculosis, potentially revitalizing the drug development pipeline.

More Related Videos

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
10:29

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis

Published on: March 24, 2017

8.4K
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

2.3K

Related Experiment Videos

Last Updated: Mar 11, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

9.2K
A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
10:29

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis

Published on: March 24, 2017

8.4K
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

2.3K

Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Microbiology

Background:

  • Natural products (NPs) have historically yielded essential drugs for tuberculosis (TB).
  • The current clinical TB drug pipeline lacks novel candidates derived from new NP scaffolds.
  • There is a critical need for new anti-TB agents due to rising drug resistance.

Purpose of the Study:

  • To highlight recent discoveries of novel natural products and analogs with activity against Mycobacterium tuberculosis (Mtb).
  • To emphasize the potential of these compounds to address the scarcity in the TB drug development pipeline.

Main Methods:

  • Literature review of recent natural product discoveries.
  • Screening of novel NP structures and known NP classes for anti-Mtb activity.
  • Analysis of structure-activity relationships for promising compounds.

Main Results:

  • Numerous novel NPs and NP analogs exhibit significant activity against Mtb.
  • Previously unrecognized NP classes have demonstrated anti-Mtb potential.
  • These findings indicate a promising pool of candidates for TB drug development.

Conclusions:

  • Recent natural product research offers a valuable resource to replenish the TB drug pipeline.
  • Novel and known natural product-derived compounds show promise for treating tuberculosis.
  • These discoveries could lead to improved therapeutic strategies against this devastating disease.