Neonatal Cholestasis - Single Centre Experience in Central India.

Area of Science:

• Pediatrics
• Neonatology
• Gastroenterology

Background:

• Neonatal cholestasis syndrome (NCS) is a significant cause of infant morbidity and mortality.
• Limited research exists on NCS in Central India.

Purpose of the Study:

• To determine the prevalence of NCS.
• To describe the clinical presentation and etiology of NCS.
• To investigate NCS at a tertiary referral center in Central India.

Main Methods:

• A descriptive study analyzing records of suspected NCS patients.
• Data collected from a tertiary referral center in Central India.
• Records from 2007-2012 were reviewed for 100 infants.

Main Results:

• Common clinical features include jaundice (100%), failure to thrive (73%), and organomegaly (68%).
• The male to female ratio was 1.17:1.
• Etiologies identified: biliary atresia (41%), neonatal hepatitis (20%), and idiopathic neonatal hepatitis (18%).

Conclusions:

• NCS prevalence was 1.2 per 1000 patients.
• Jaundice, organomegaly, and failure to thrive are characteristic presentations.
• Biliary atresia and neonatal hepatitis are prevalent etiological factors in this region.