Epidemiological study of occupational exposure to hepatitis B virus and liver function tests

A total of 1020 hospital employees were divided into an exposure group (n = 725) and a non-exposure group (n = 295), based on whether they had been exposed to blood from patients. The HBsAg-positive rates for the exposure and the non-exposure groups were 2.48% and 1.02%, respectively. In the exposure group, the minimal exposure rate increased with age from the twenties. The odds ratios were 7.39 in the technicians, 4.38 in physicians and 1.32 in nurses. Using age-sex matched pairs from the exposure and non-exposure groups, comparison of aspartate aminotransferase, alanine amino-transferase and guanase activities showed that there were significantly higher values in HBsAg-positive subjects (n = 18) from the exposure group than in HBsAg- and HBsAb-negative subjects from the non-exposure group (p less than 0.05-0.01). However, no significant differences were found in the enzyme activities in the matched pairs (n = 89) of HBsAb-positive subjects from the exposure and non-exposure groups.