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Hypersensitivity with Inhalational Budesonide: An Under Recognised Entity
Pramod Kumar Sharma1, Neeraj Gupta2, Najmul Hasan3
1Associate Professor, Department of Pharmacology, AIIMS , Jodhpur, Rajasthan, India .
Journal of Clinical and Diagnostic Research : JCDR
|November 29, 2016
Summary
Hypersensitivity reactions to inhaled budesonide are rare but possible. This case report details a rare adverse effect of budesonide causing allergic reactions in a child.
Area of Science:
- Pharmacology
- Allergy and Immunology
Background:
- Hypersensitivity reactions are common with many drugs, but corticosteroids are typically used to treat them.
- Corticosteroids are generally considered safe, making drug-induced hypersensitivity to them unlikely.
Observation:
- A rare case of hypersensitivity reaction to inhaled budesonide occurred in an 8-year-old boy.
- The patient presented with maculopapular rashes and pruritus within hours of the first dose.
- Symptoms resolved upon drug withdrawal and antihistamine treatment, recurring upon re-administration.
Findings:
- Causality analysis indicated a probable association between inhaled budesonide and the observed allergic reaction.
- The patient had a family history of allergic rhinitis, suggesting a potential allergic predisposition.
Implications:
- This case highlights the possibility of budesonide-induced hypersensitivity, even though rare.
- Clinicians should consider inhaled budesonide as a potential cause of allergic reactions in susceptible individuals.
- Further investigation into budesonide hypersensitivity mechanisms may be warranted.
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