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Related Experiment Video

Updated: Mar 11, 2026

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
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Myocardial strain to detect subtle left ventricular systolic dysfunction.

Laurens F Tops1, Victoria Delgado1, Nina Ajmone Marsan1

  • 1Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.

European Journal of Heart Failure
|November 29, 2016
PubMed
Summary
This summary is machine-generated.

Left ventricular global longitudinal strain (LV GLS) offers a more sensitive measure of systolic function than ejection fraction (EF). This review highlights LV GLS

Keywords:
Heart failure with preserved LVEFLVEFLeft ventricular systolic dysfunctionSpeckle tracking echocardiography

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Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
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Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
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Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

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Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiac Physiology

Background:

  • Left ventricular (LV) systolic function is routinely assessed using two-dimensional echocardiography to calculate LV ejection fraction (LVEF).
  • While real-time three-dimensional echocardiography enhances LVEF accuracy, LVEF may not fully represent LV systolic function in certain conditions or with subtle dysfunction.
  • Two-dimensional speckle tracking echocardiography (2DSTE) provides detailed myocardial strain assessment, offering insights into global and regional LV deformation.

Purpose of the Study:

  • To review the utility of LV global longitudinal strain (GLS) in detecting subtle LV systolic dysfunction.
  • To illustrate the application of LV GLS in various clinical scenarios where LVEF may be preserved despite underlying dysfunction.

Main Methods:

  • Review of existing literature and clinical data on echocardiographic assessment of LV systolic function.
  • Focus on the application of 2DSTE for myocardial strain analysis, specifically LV GLS.
  • Discussion of clinical scenarios demonstrating the value of LV GLS over traditional LVEF measurements.

Main Results:

  • LV GLS provides more detailed information on global and regional LV deformation compared to LVEF.
  • Subtle LV systolic dysfunction can be detected by LV GLS even when LVEF is preserved.
  • LV GLS has demonstrated potential in identifying dysfunction in various cardiac diseases.

Conclusions:

  • LV GLS is a valuable tool for detecting subtle LV systolic dysfunction, particularly when LVEF is preserved.
  • Myocardial strain analysis using 2DSTE, specifically LV GLS, offers crucial insights beyond traditional LVEF assessment.
  • The review underscores the importance of incorporating LV GLS into clinical practice for comprehensive evaluation of LV systolic function.