Pd-mediated cross-coupling of C-17 lithiated androst-16-en-3-ol - access to functionalized arylated steroid
1Institute of Organic Chemistry, Karlsruhe Institute of Technology - Campus South, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany. stefan.braese@kit.edu.
Abstract:
Herein, we report on Pd-mediated cross-coupling of vinyllithium steroids and aryl bromides to introduce various substituted aryls at C-17 of steroidal frameworks based on the structure of epi-androsterone. Compared to other C-C cross-couplings, this method turned out to be an easy and competitive access to biologically interesting C-17 modified steroids.
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