An advanced mouse model for human skin wound healing
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Murine Model of Wound Healing
Published on: May 28, 2013
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Jie Wen1, Xiangyong Li1,2, Xue Leng1
1Laboratory for Tissue Engineering and Regeneration, School of Stomatology, Shandong University, Jinan, Shandong, China.
Experimental Dermatology
|November 29, 2016
Abstract:
Here, we report a model for studying wound repair based on skin regenerated from human tissue culture-expanded cells. The reconstituted skin (hRSK) responds to injury similar to that of intact human skin, and its constituent cells contribute to the healing process. As we have demonstrated that hRSK composed of GFP-labelled cells also heals "normally," we believe this model will be useful in analysing the wound repair process using genetically modified human cells.
