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Converting Red Blood Cells to Efficient Microreactors for Blood Detoxification.

Can Xu1,2, Xiangyu Yang2, Xiao Fu2

  • 1Department of PET Center, Xiangya Hospital, Central South University, Changsha, 410008, China.

Advanced Materials (Deerfield Beach, Fla.)
|November 29, 2016
PubMed
Summary

Researchers developed a simple method to transform red blood cells (RBCs) into efficient microreactors. These engineered RBCs show potential for blood detoxification applications.

Keywords:
Triton X-100 (TX)blood detoxificationglutaraldehyde (GA)microreactorsred blood cells (RBC)

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Area of Science:

  • Biotechnology
  • Biomaterials Engineering
  • Cellular Engineering

Background:

  • Red blood cells (RBCs) are abundant and biocompatible, offering potential as cellular platforms.
  • Existing methods for cellular microreactor fabrication are often complex or inefficient.

Purpose of the Study:

  • To develop a straightforward method for converting RBCs into functional microreactors.
  • To demonstrate the application of these RBC-derived microreactors in blood detoxification.

Main Methods:

  • Utilizing specific concentrations of Triton X-100 to permeabilize RBC membranes.
  • Employing low concentrations of glutaraldehyde for cell stabilization.
  • Assessing the microreactor capabilities for substrate processing.

Main Results:

  • Successfully rendered RBCs permeable to substrates while maintaining cellular integrity.
  • Demonstrated the capacity of engineered RBCs to act as microreactors.
  • Showcased the potential for blood detoxification using these novel microreactors.

Conclusions:

  • A simple and effective method exists to convert RBCs into microreactors.
  • These RBC-based microreactors hold promise for biomedical applications, including detoxification.
  • Further research can explore expanded applications of this RBC engineering technique.