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Left ventricular diastolic dysfunction in patients with ST-elevation myocardial infarction following early and late

Xianghui Chen1, Fucheng Liu1, Honggui Xu1

  • 1Department of Cardiology, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China.

International Journal of Cardiology
|November 29, 2016
PubMed

Insights

Most ST-elevation myocardial infarction patients have diastolic dysfunction post-PCI. Early reperfusion did not significantly improve left ventricular diastolic function compared to late reperfusion in the acute phase.

Area of Science:

  • Cardiology
  • Echocardiography
  • Acute Coronary Syndromes

Background:

  • Left ventricular (LV) diastolic dysfunction is common in ST-elevation myocardial infarction (STEMI) patients.
  • The impact of reperfusion timing on diastolic function recovery remains an area of investigation.

Purpose of the Study:

  • To assess changes in LV diastolic function in STEMI patients post-PCI.
  • To compare diastolic function recovery between early (<6 hours) and late (≥6 hours) reperfusion groups.

Main Methods:

  • Prospective study of 45 STEMI patients treated with PCI.
  • Patients divided into early (<6h) and late (≥6h) total ischemia time (TIT) groups.
  • Transthoracic echocardiography assessed diastolic function using integrated Doppler methods.

Main Results:

  • 80% of patients exhibited abnormal diastolic filling patterns post-PCI.
  • Early reperfusion group showed lower septal e' velocity compared to the late group (P<0.05).
  • No significant differences were observed in E/e' average, left atrial volume index, or mitral annulus propagation velocity between groups.

Conclusions:

  • LV diastolic dysfunction is prevalent in STEMI patients even after successful PCI.
  • Early myocardial reperfusion did not demonstrate superior diastolic function recovery compared to late reperfusion in the acute phase.
Abstract

Keywords:
EchocardiographyLeft ventricular diastolic functionMyocardial infarction

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