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Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Updated: Mar 11, 2026

Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients
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Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients

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Stem cells in psoriasis.

Ruixia Hou1, Junqin Li1, Xuping Niu1

  • 1Institute of Dermatology, Taiyuan City Central Hospital, Shanxi Key Laboratory for Immunological Dermatosis, No. 1 Dong San Dao Xiang, Taiyuan, Shanxi, 030009, China.

Journal of Dermatological Science
|November 30, 2016
PubMed
Summary
This summary is machine-generated.

Psoriasis involves complex interactions across multiple body systems. Recent research highlights abnormalities in stem cells contributing to this chronic inflammatory disease.

Keywords:
Mesenchymal stem cellsPsoriasisStem cells

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Area of Science:

  • Dermatology and immunology
  • Cell biology

Background:

  • Psoriasis is a chronic, relapsing inflammatory condition with complex underlying mechanisms.
  • Its development involves interactions between the epidermis, dermis, immune, neuroendocrine, metabolic, and hematopoietic systems.
  • Numerous cell types are implicated in psoriasis pathogenesis.

Purpose of the Study:

  • To review recent investigations into stem cell abnormalities associated with psoriasis.
  • To consolidate current understanding of stem cell roles in psoriasis development.

Main Methods:

  • Literature review of recent scientific studies.
  • Analysis of research focusing on stem cell biology in the context of psoriasis.

Main Results:

  • Stem cell abnormalities are increasingly recognized as a factor in psoriasis.
  • Specific stem cell populations and their dysfunctions are implicated in the disease process.

Conclusions:

  • Stem cell dysfunction represents a significant area of investigation for psoriasis.
  • Understanding these abnormalities may offer new therapeutic targets for psoriasis management.