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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Related Experiment Video

Updated: Mar 11, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

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Cancer stem cells in osteosarcoma.

Hannah K Brown1, Marta Tellez-Gabriel2, Dominique Heymann3

  • 1Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, S10 2RX, Sheffield, UK; European Associated Laboratory, INSERM-University of Sheffield, Sarcoma Research Unit, Medical School, S10 2RX, Sheffield, UK.

Cancer Letters
|November 30, 2016
PubMed
Summary
This summary is machine-generated.

Osteosarcoma, a common childhood bone cancer, often resists treatment. Cancer stem cells (CSCs) drive tumor growth and therapy resistance, necessitating new therapeutic targets and improved treatments for osteosarcoma.

Keywords:
Bone cancerCancer stem cellOsteosarcomaTumour heterogeneity

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A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
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A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
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A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

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Area of Science:

  • Oncology
  • Cancer Biology
  • Molecular Medicine

Background:

  • Osteosarcoma is the most frequent primary bone tumor in pediatric and adolescent populations.
  • Advanced osteosarcoma with metastasis is associated with a poor prognosis.
  • Resistance to standard therapies is common in osteosarcoma, underscoring the need for novel therapeutic strategies.

Purpose of the Study:

  • To review the role of cancer stem cells (CSCs) in osteosarcoma.
  • To discuss methods for isolating CSCs in osteosarcoma.
  • To identify key biochemical and molecular markers associated with osteosarcoma CSCs.

Main Methods:

  • Literature review of published research on osteosarcoma and cancer stem cells.
  • Analysis of common techniques for CSC isolation in osteosarcoma models.
  • Compilation of identified CSC markers in osteosarcoma.

Main Results:

  • Cancer stem cells (CSCs) are implicated in tumor propagation, therapy resistance, recurrence, and metastasis of osteosarcoma.
  • Evidence suggests CSC phenotypes contribute to drug resistance and tumorigenesis in osteosarcoma.
  • Various isolation techniques and molecular markers for osteosarcoma CSCs have been reported.

Conclusions:

  • CSCs are a significant factor in osteosarcoma progression and treatment failure.
  • Understanding CSC markers and isolation methods is crucial for developing targeted therapies.
  • Targeting CSCs may offer a promising avenue for improving osteosarcoma treatment outcomes.