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Updated: Mar 11, 2026

In Vitro Assay to Study Tumor-macrophage Interaction
Published on: August 1, 2019
Molecular Pathways: Deciphering Mechanisms of Resistance to Macrophage-Targeted Therapies
Daniela F Quail1,2, Johanna A Joyce3,4
1Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Abstract:
Tumor-associated macrophages (TAMs) are a major cellular component of numerous tumor types. TAM-targeted therapies include depletion strategies, inhibiting their effector functions or reprogramming toward an antitumorigenic phenotype, with varying degrees of efficacy. Here, we review preclinical and clinical strategies to target macrophages in cancer and discuss potential explanations for why some strategies are effective while other approaches have shown limited success. Clin Cancer Res; 23(4); 876-84. ©2016 AACR.
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