Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adherens Junctions01:24

Adherens Junctions

7.3K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
7.3K
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

10.4K
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
10.4K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

9.6K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
9.6K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

3.8K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.8K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

6.0K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endothelial cell-derived plasminogen activator inhibitor-1 potentiates thrombosis in antiphospholipid syndrome.

Journal of autoimmunity·2026
Same author

Correction: A proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry.

Frontiers in immunology·2026
Same author

Do ethnoracial differences exist among antiphospholipid antibody-positive patients with no other systemic autoimmune diseases: results from the APS ACTION registry.

Advances in rheumatology (London, England)·2026
Same author

Neutrophils and monocytes in the pathogenesis of antiphospholipid syndrome.

Current opinion in immunology·2026
Same author

Antiphospholipid antibodies and cardiovascular thrombosis.

Nature reviews. Cardiology·2026
Same author

Molecular Stratification of Antiphospholipid Syndrome Through Integrative Analysis of the Whole-Blood RNA Transcriptome.

Arthritis & rheumatology (Hoboken, N.J.)·2025

Related Experiment Video

Updated: Mar 11, 2026

Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli
14:05

Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli

Published on: November 4, 2022

3.1K

Intercellular Interactions as Regulators of NETosis.

Nayef M Kazzaz1, Gautam Sule1, Jason S Knight1

  • 1Department of Internal Medicine, Division of Rheumatology, University of Michigan , Ann Arbor, MI , USA.

Frontiers in Immunology
|November 30, 2016
PubMed
Summary

Neutrophil extracellular traps (NETs) are released by neutrophils. Cellular partners like platelets and endothelial cells significantly influence NETosis in vivo, requiring further study in disease states.

Keywords:
endotheliumintegrinsneutrophil extracellular trapsplateletsselectins

More Related Videos

Real-Time, High-Throughput Microscopic Quantification of Human Neutrophil Extracellular Trap Release and Assessing the Pharmacology of Antagonists
11:32

Real-Time, High-Throughput Microscopic Quantification of Human Neutrophil Extracellular Trap Release and Assessing the Pharmacology of Antagonists

Published on: October 18, 2024

1.2K
Author Spotlight: Neutrophil Extracellular Traps Imaging in Human and Mouse Tissues
07:36

Author Spotlight: Neutrophil Extracellular Traps Imaging in Human and Mouse Tissues

Published on: August 18, 2023

9.6K

Related Experiment Videos

Last Updated: Mar 11, 2026

Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli
14:05

Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli

Published on: November 4, 2022

3.1K
Real-Time, High-Throughput Microscopic Quantification of Human Neutrophil Extracellular Trap Release and Assessing the Pharmacology of Antagonists
11:32

Real-Time, High-Throughput Microscopic Quantification of Human Neutrophil Extracellular Trap Release and Assessing the Pharmacology of Antagonists

Published on: October 18, 2024

1.2K
Author Spotlight: Neutrophil Extracellular Traps Imaging in Human and Mouse Tissues
07:36

Author Spotlight: Neutrophil Extracellular Traps Imaging in Human and Mouse Tissues

Published on: August 18, 2023

9.6K

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Neutrophil extracellular traps (NETs) are DNA webs extruded by neutrophils during infection or sterile inflammation.
  • NETosis is primarily studied in vitro, but in vivo conditions involve complex cellular interactions.

Approach:

  • Investigates in vitro co-cultures and animal models (sepsis, thrombosis, etc.) to understand NETosis.
  • Examines the roles of platelets and endothelial cells in modulating neutrophil extracellular trap release.

Key Points:

  • Platelet-neutrophil interactions, involving selectins and integrins, influence NETosis.
  • Soluble mediators from platelets (e.g., alarmins) and endothelial cell interactions also regulate NETosis.
  • Shared molecular markers on platelets and endothelium complicate in vivo data interpretation.

Conclusions:

  • Neutrophil engagement with activated cellular partners is a key in vivo signal for NETosis.
  • Future research should focus on the interplay of neutrophils, platelets, and endothelium in disease-related NETosis.