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Assessing Absorption Coefficient of Hemoglobin in the Breast Phantom Using Near-Infrared Spectroscopy
Parinaz Mehnati1, Maede Jafari Tirtash1, Mohammad Sadegh Zakerhamidi2
1Department of Medical Physics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Background:
Blood concentrations and oxygen saturation levels are important biomarkers for breast cancer diagnosis.
Objectives:
In this study, the absorption coefficient of hemoglobin (Hb) was used to distinguish between normal and abnormal breast tissue.
Materials And Methods:
A near-infrared source (637 nm) was transmitted from major and minor vessels of a breast phantom containing 2×, 4× concentrations of oxy- and deoxy-Hb. The absorption coefficients were determined from spectrometer (SM) and powermeter (PM) data.
Results:
The absorption coefficients were 0.075 ± 0.026 cm-1 for oxygenated Hb (normal) in major vessels and 0.141 ± 0.023 cm-1 at 4× concentration (abnormal) with SM, whereas the breast absorption coefficients were 0.099 ± 0.017 cm-1 for oxygenated Hb (normal) in minor vessels and 0.171 ± 0.005 cm-1 at 4× concentrations with SM. A comparison of the data obtained using a SM and a PM was not significant statistically.
Conclusion:
The study of the absorption coefficient data of different concentrations of Hb in normal and abnormal breasts via the diffusion of near-infrared light is a valuable method and has the potential to aid in early detection of breast abnormalities with SM and PM in major and minor vessels.
