Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coagulation01:09

Coagulation

11.5K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
11.5K
Introduction to Hemostasis01:05

Introduction to Hemostasis

15.7K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
15.7K
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

14.5K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
14.5K
Disorders of Hemostasis01:24

Disorders of Hemostasis

2.6K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.6K
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

609
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
609
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

2.2K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of ethynylestradiol-3-sulfate on coagulation, metabolism, and survival in pigs with traumatic hemorrhage.

The journal of trauma and acute care surgery·2023
Same author

Valproic acid during hypotensive resuscitation in pigs with trauma and hemorrhagic shock does not improve survival.

The journal of trauma and acute care surgery·2022
Same author

Hypothermia Induced Impairment of Platelets: Assessment With Multiplate vs. ROTEM-An <i>In Vitro</i> Study.

Frontiers in physiology·2022
Same author

Autoresuscitation of Poloxamer 188 in Pigs With Traumatic Severe Hemorrhage.

Shock (Augusta, Ga.)·2021
Same author

Muscle deteriorations become prominent within 24 hours after admission in severely burned adults.

The journal of trauma and acute care surgery·2021
Same author

Hypothermia-Associated Coagulopathy: A Comparison of Viscoelastic Monitoring, Platelet Function, and Real Time Live Confocal Microscopy at Low Blood Temperatures, an <i>in vitro</i> Experimental Study.

Frontiers in physiology·2020

Related Experiment Video

Updated: Mar 11, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.8K

Coagulation complications following trauma.

Wenjun Z Martini1

  • 1U.S. Army Institute of Surgical Research, 3698 Chambers Pass, JBSA-Fort Sam Houston, Houston, TX 78234-6315 USA.

Military Medical Research
|November 30, 2016
PubMed
Summary
This summary is machine-generated.

Traumatic injury can cause early coagulopathy, a bleeding complication linked to hypothermia, acidosis, and hemodilution. Understanding this early dysfunction is key to improving trauma patient outcomes and reducing mortality.

Keywords:
CoagulationLethal triadPathophysiologySepsisTraumatic injury

More Related Videos

Integrated Compensatory Responses in a Human Model of Hemorrhage
07:57

Integrated Compensatory Responses in a Human Model of Hemorrhage

Published on: November 20, 2016

13.2K
Complete and Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Hemorrhagic Shock
06:30

Complete and Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Hemorrhagic Shock

Published on: May 19, 2022

8.1K

Related Experiment Videos

Last Updated: Mar 11, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.8K
Integrated Compensatory Responses in a Human Model of Hemorrhage
07:57

Integrated Compensatory Responses in a Human Model of Hemorrhage

Published on: November 20, 2016

13.2K
Complete and Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Hemorrhagic Shock
06:30

Complete and Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Hemorrhagic Shock

Published on: May 19, 2022

8.1K

Area of Science:

  • Trauma and Emergency Medicine
  • Hematology
  • Coagulation Science

Background:

  • Traumatic injury is a leading cause of death, with uncontrolled hemorrhage a major contributor.
  • Coagulation dysfunction (coagulopathy) is a significant factor in trauma mortality.
  • The 'lethal triad' of hypothermia, acidosis, and hemodilution contributes to trauma-induced coagulopathy.

Purpose of the Study:

  • To review current knowledge on coagulation complications following traumatic injury.
  • To highlight the early onset of coagulopathy in trauma patients.
  • To discuss the pathophysiology and clinical implications of trauma-induced coagulopathy.

Main Methods:

  • Literature review of current research on trauma-induced coagulopathy.
  • Analysis of clinical observations regarding early coagulopathy.
  • Synthesis of information on the lethal triad and hemostatic dysfunction.

Main Results:

  • Coagulopathy can be present upon hospital admission in severely injured trauma patients.
  • Early hemostatic dysfunction is associated with increased transfusion needs, prolonged hospitalization, and higher mortality.
  • Recognition of early coagulopathy drives research into its underlying mechanisms and improved treatments.

Conclusions:

  • Early recognition and understanding of trauma-induced coagulopathy are critical for improving patient survival.
  • Further research is needed to elucidate the pathophysiology and optimize clinical management of coagulopathy in trauma.
  • Addressing coagulopathy is essential for reducing preventable deaths from traumatic injury.