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Disease-associated marked hyperalphalipoproteinemia

Ken-Ichi Hirano1, Hironori Nagasaka2, Kazuhiro Kobayashi3

  • 1Laboratory of Cardiovascular Disease, Novel, Non-invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University, Osaka 565-0874, Japan.

Molecular Genetics and Metabolism Reports
|November 30, 2016
PubMed

Marked hyperalphalipoproteinemia (HAL) is a heterogeneous syndrome. To clarify the pathophysiological significance of HAL, we compared clinical profiles between marked HAL subjects with and without cholesteryl ester transfer protein (CETP) deficiency. CETP deficiency was associated with cardiovascular diseases and strokes in the HAL population, particularly in female. HAL women without CETP deficiency tended to have higher prevalence with cancer history. HAL may not always be a longevity marker, but be sometimes accompanied with pathological conditions.

Keywords:
AtherosclerosisCardiovascular diseaseCholesteryl ester transfer protein deficiencyHigh density lipoproteinHyperalphalipoproteinemiaStroke

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