Related Experiment Videos
Synthesis of disubstituted tetrahydrocarbazoles with potential antidepressive activity
G I Giancaspro1, M T Pizzorno, S M Albonico
1Iquimefa-Conicet-Facultad de Farmacia y Bioquimica Universidad de Buenos Aires, Argentina.
Farmaco (Societa Chimica Italiana : 1989)
|May 1, 1989
Abstract:
A new series of disubstituted tetrahydrocarbazoles were synthesized. They are tested for antidepressive activity by the Porsolt's forced swimming test (one of the acute stress methods) and by the prevention of reserpine induced hypothermia and ptosis in mice. 3-Morpholino-1-[N-(6-methoxy-1,2,3,4- tetrahydrocarbozolyl)2-propanol, fumarate (XI) was demonstrated to be the most promising compound of this series. Besides, this series did not present the most common adverse effects of the conventional tricyclic-antidepressants (loss of locomotor coordination, ataxia and anticholinergic activity).