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Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
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Basement membrane ultrastructure and component localization data from uterine tissues during early mouse pregnancy
Celestial R Jones-Paris1, Sayan Paria2, Taloa Berg2
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States; Aspirnaut, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Data in Brief
|November 30, 2016
Summary
Basement membranes (BMs) dynamically change during pregnancy in mice. These alterations in uterine tissue structure are crucial for successful embryo implantation and maternal-embryo interactions.
Area of Science:
- Reproductive biology
- Cell biology
- Biochemistry
Background:
- Basement membranes (BMs) are essential extracellular scaffolds providing tissue structure and regulating cell behavior.
- BMs are typically stable in adult tissues but undergo significant changes in the uterus during pregnancy.
- These changes are vital for early maternal-embryo interactions and successful implantation.
Purpose of the Study:
- To investigate the dynamic changes in basement membrane (BM) properties within uterine tissues during the critical periods of early pregnancy.
- To understand the spatial-temporal regulation of BM properties during uterine reprogramming for embryo implantation.
- To correlate BM alterations with physiological adaptations required for pregnancy.
Main Methods:
- Tracking of static and dynamic basement membranes (BMs) in mouse uterine tissues.
- Analysis of BM ultrastructure, composition, and localization.
- Observation across pre-, peri-, and postimplantation stages of pregnancy.
Main Results:
- Demonstrated the presence of both static and dynamic basement membranes (BMs) in the mouse uterus during early pregnancy.
- Revealed distinct spatial-temporal patterns in BM property regulation.
- Showed that these BM alterations coincide with the progression of physiological adaptations necessary for pregnancy.
Conclusions:
- Basement membrane (BM) remodeling is a dynamic and spatially regulated process during uterine reprogramming for pregnancy.
- These BM changes are integral to facilitating embryo implantation and supporting early maternal-embryo interactions.
- The study highlights the plasticity of BMs in adapting to the physiological demands of pregnancy.
Keywords:
Basement membrane
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