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Predictors of motor developmental milestones during the first year of life
Trine Flensborg-Madsen1,2, Erik Lykke Mortensen3,4
1Unit of Medical Psychology, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5A, 1353, Copenhagen K, Denmark. tfma@sund.ku.dk.
Insights
Pregnancy and delivery factors, like gestational age and birth weight, are key predictors of infant developmental milestones. These prenatal influences explain the most variance in achieving milestones during the first year of life.
Area of Science:
- Developmental Psychology
- Pediatrics
- Perinatal Medicine
Background:
- Both prenatal and postnatal factors influence infant developmental milestone attainment.
- Previous studies have not comparatively evaluated the predictive strength of these factors.
- Understanding these predictors is crucial for identifying developmental trajectories.
Purpose of the Study:
- To systematically evaluate a wide range of prenatal and postnatal predictors of infant milestone attainment.
- To determine which factors explain the most significant inter-individual variance in development.
- To compare the explanatory power of different predictor domains.
Main Methods:
- Prospective data collection from 5765 children in the Copenhagen Perinatal Cohort (1959-61).
- Recording of 12 developmental milestones during the first year of life.
- Categorization of predictors into Family background, Pregnancy and delivery, Postnatal influences, and Postnatal growth domains.
Main Results:
- The Pregnancy and delivery domain explained the largest proportion of variance (14.4%) in overall milestone attainment.
- Gestational age (β = -0.15) and birth weight (β = -0.16) were particularly significant predictors.
- The predictive power of factors decreased over time for later milestones.
Conclusions:
- Gestational age and birth weight are critical prenatal predictors of infant milestone attainment.
- Breastfeeding, institutional living, and infant growth (weight and head circumference) in the first year also showed significant associations.
- Prenatal factors, especially those related to pregnancy and delivery, are the strongest contributors to explaining variance in early infant development.
Abstract:
Studies suggest that both pre- and postnatal factors are predictors of age of attaining milestones in infancy. However, no studies evaluate the comparative strength of these predictors and the amount of the variance in development they explain. This study aimed to conduct a systematic evaluation of a broad selection of possible predictors of age at milestone attainment and to identify factors that explain significant inter-individual variance. Mothers of 5765 children of the Copenhagen Perinatal Cohort (1959-61) recorded 12 developmental milestones prospectively during the child's first year of life. Information on possible predictors was collected during pregnancy and at follow-up and was categorized into the domains: Family background, Pregnancy and delivery, Postnatal influences, and Postnatal growth. The domain Pregnancy and delivery contributed most of the explained variance in Overall mean of milestones (14.4%), with especially gestational age (β = -0.15; p ≤ 0.001) and birth weight (β = -0.16; p ≤ 0.001) being important predictors.
Conclusion:
Several individual factors, especially gestational age, birth weight, breastfeeding, having lived in a full-time institution, and weight and head increase in the first year, were significantly associated with milestone attainment in the first year of life. Variables within the domain of Pregnancy and delivery explained the largest proportion of variance in milestone attainment compared to the other domains. What is known: • Younger age at attainment of motor developmental milestones positively predicts cognitive outcomes in adulthood. • Both pre- and postnatal factors have been associated with age of attaining milestones in infancy. What is new: • First study to provide a systematic evaluation of a broad selection of predictors of infant milestone attainment. • Variables within the domain of Pregnancy and delivery, especially gestational age and birth weight, explained the largest proportion of variance in milestone attainment. • The variance explained by the predictors decreased time-dependently with later milestones.
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