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Blood Bio-Sampling Procedures for Multiplex Biomarkers Studies.

Paul C Guest1, Hassan Rahmoune2

  • 1Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Rua Monteiro Lobato 255 F/01, Cidade Universitária ZeferinoVaz, 13083-862, Campinas, Brazil.

Methods in Molecular Biology (Clifton, N.J.)
|November 30, 2016
PubMed
Summary
This summary is machine-generated.

Standardizing sample collection and handling is crucial for reliable biomarker discovery. This ensures analyte stability and compatibility with profiling platforms, advancing personalized medicine and companion diagnostics.

Keywords:
Bio-processingBio-samplingBiomarkersPlasmaSerum

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Area of Science:

  • Biomarker Discovery and Validation
  • Translational Medicine
  • Clinical Diagnostics

Background:

  • Disease heterogeneity and treatment variability complicate biomarker discovery.
  • Lack of standardized protocols for biological fluid handling (plasma, serum) hinders blood-based biomarker test development.
  • Inconsistent sample processing impacts preclinical and clinical research reproducibility.

Purpose of the Study:

  • To present a reproducible procedure for biological sample collection and handling.
  • To enhance analyte stability for multiplex biomarker profiling.
  • To ensure compatibility between sample handling and biomarker profiling platforms.

Main Methods:

  • Development of a standardized protocol for biological sample acquisition and processing.
  • Focus on maintaining analyte integrity during storage and handling.
  • Validation of the protocol for use with multiplex biomarker profiling platforms.

Main Results:

  • The proposed procedure enhances analyte stability in biological samples.
  • The protocol ensures compatibility with multiplex biomarker profiling platforms.
  • Improved reproducibility in blood-based biomarker measurements.

Conclusions:

  • Standardized bio-sample acquisition and processing are essential for successful biomarker measurement.
  • Defined guidelines for study design and profiling platforms are critical for personalized healthcare.
  • This reproducible method supports the development of reliable companion diagnostics.