Related Experiment Video
Updated: Mar 11, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Estimation of state occupancy probabilities in multistate models with dependent intermittent observation, with
1Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, 60 Murray Street, Toronto, M5T 3L9, ON, Canada.
Abstract:
In follow-up studies on chronic disease cohorts, individuals are often observed at irregular visit times that may be related to their previous disease history and other factors. This can produce bias in standard methods of estimation. Working in the context of multistate models, we consider a method of nonparametric estimation for state occupancy probabilities that adjusts for dependent follow-up through the use of inverse-intensity-of-visit weighted estimating functions and smoothing. The methodology is applied to the estimation of viral rebound probabilities in the Canadian Observational Cohort on HIV-positive persons. Copyright © 2016 John Wiley & Sons, Ltd.
Related Concept Videos
Steps in Outbreak Investigation
Assumptions of Survival Analysis
Probability Histograms
Mechanistic Models: Compartment Models in Individual and Population Analysis
Censoring Survival Data
Kaplan-Meier Approach

