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Updated: Mar 11, 2026

Electrophysiological Recording of The Central Nervous System Activity of Third-Instar Drosophila Melanogaster
Published on: November 21, 2018
Mesoionic insecticides: a novel class of insecticides that modulate nicotinic acetylcholine receptors
Caleb W Holyoke1, Daniel Cordova1, Wenming Zhang1
1DuPont Crop Protection, Stine-Haskell Research Center, Newark, DE, USA.
Background:
As the world population grows towards 9 billion by 2050, it is projected that food production will need to increase by 60%. A critical part of this growth includes the safe and effective use of insecticides to reduce the estimated 20-49% loss of global crop yields owing to pests. The development of new insecticides will help to sustain this protection and overcome insecticide resistance.
Results:
A novel class of mesoionic compounds has been discovered, with exceptional insecticidal activity on a range of Hemiptera and Lepidoptera. These compounds bind to the orthosteric site of the nicotinic acetylcholine receptor and result in a highly potent inhibitory action at the receptor with minimal agonism. The synthesis, biological activity, optimization and mode of action will be discussed.
Conclusion:
Triflumezopyrim insect control will provide a powerful tool for control of hopper species in rice throughout Asia. Dicloromezotiaz can provide a useful control tool for lepidopteran pests, with an underexploited mode of action among these pests. © 2016 Society of Chemical Industry.
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