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Updated: Mar 11, 2026
Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
Published on: February 14, 2021
Hepatic Histological Changes in Ulcerative Colitis
F T de Dombal1, W Goldie1, J McK Watts1
1a University Department of Surgery , The General Infirmary, Leeds, and Department of Pathology, St. James Hospital , Leeds , England.
Abstract:
Operative liver biopsy was performed on 58 consecutive patients coming to radical excisional surgery for ulcerative colitis. The histological changes seen in the liver were: increased cellularity of the portal tracts (83 per cent); fatty infiltration (83 per cent); areas of focal necrosis (47 per cent); and early cirrhosis (2 per cent). Severe liver damage was shown to he associated with severe active colitis, and with a poor subsequent post-operative prognosis. The mechanisms responsible for liver damage in patients with colitis are discussed.
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