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Published on: November 2, 2015
Effect of intermittent hypoxic training on hypoxia tolerance based on brain functional connectivity
Guang Li1, Tinglin Zhang, Xiaojian Chen
1State Key Laboratory of Industrial Control Technology, Zhejiang University, 38 Zheda Road, Hangzhou 310027, People's Republic of China. Department of Control Science and Engineering, Zhejiang University, 38 Zheda Road, Hangzhou 310027, People's Republic of China.
Intermittent hypoxic training enhances brain hypoxia tolerance. Brain connectivity changes during hypoxia appear before mental fatigue, indicating improved resilience after training.
Area of Science:
- Neuroscience
- Physiology
Background:
- Hypoxia affects brain function and connectivity.
- Intermittent hypoxic training may improve brain's adaptation to hypoxia.
- Understanding brain network changes during hypoxia is crucial.
Purpose of the Study:
- To investigate brain functional connectivity differences between hypoxic and normal states.
- To evaluate the impact of intermittent hypoxic training on brain hypoxia tolerance.
- To identify early indicators of hypoxia in brain networks.
Main Methods:
- Multivariable empirical mode decomposition (MEMD) of multichannel EEG.
- Analysis of intrinsic mode functions (IMFs) for brain connectivity.
- Quantification of synchronization using coherence, phase locking value (PLV), and synchronization likelihood (SL).
Main Results:
- Both local and global functional connectivity decreased with increasing time in a hypoxic state.
- Brain connectivity alterations were detectable before conventional neurobehavioral signs of mental fatigue.
- Post-training, the decline in connectivity during hypoxia slowed, suggesting enhanced tolerance.
Conclusions:
- Brain functional connectivity is significantly altered by hypoxia.
- Intermittent hypoxic training improves the brain's resilience to hypoxic conditions.
- Brain connectivity analysis offers a sensitive method for early detection of hypoxic effects.
