Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

2.2K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
2.2K
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.8K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.8K
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

2.3K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
2.3K
Crossing Over01:34

Crossing Over

173.4K
Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
173.4K
Gastrulation01:56

Gastrulation

68.3K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
68.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chromosomes remain individualized through interphase in embryos of the tardigrade <i>Hypsibius exemplaris</i>.

Molecular biology of the cell·2025
Same author

Genomes of the entomopathogenic nematode Steinernema hermaphroditum and its associated bacteria.

Genetics·2025
Same author

Chromosomes remain individualized through interphase in embryos of the tardigrade <i>Hypsibius exemplaris</i>.

bioRxiv : the preprint server for biology·2025
Same author

Animal physiology: How do tardigrades survive intense radiation?

Current biology : CB·2025
Same author

Cell signaling facilitates apical constriction by basolaterally recruiting Arp2/3 via Rac and WAVE.

The Journal of cell biology·2025
Same author

Analyses of Xenorhabdus griffiniae genomes reveal two distinct sub-species that display intra-species variation due to prophages.

BMC genomics·2024
Same journal

Learning from stem cell-based embryo models.

Nature cell biology·2026
Same journal

Why the temporal dimension matters in cellular signalling.

Nature cell biology·2026
Same journal

Transcription factor condensates as storage.

Nature cell biology·2026
Same journal

Author Correction: Spatial regulation of VEGF receptor endocytosis in angiogenesis.

Nature cell biology·2026
Same journal

Mitochondria-endoplasmic reticulum contact sites as hubs where mitochondria acquire iron.

Nature cell biology·2026
Same journal

Cis and trans regulatory mechanisms of extrachromosomal DNA segregation.

Nature cell biology·2026
See all related articles

Related Experiment Video

Updated: Mar 11, 2026

A Simple and Effective Transplantation Device for Zebrafish Embryos
06:59

A Simple and Effective Transplantation Device for Zebrafish Embryos

Published on: August 2, 2021

4.2K

Remodelling germ cells by intercellular cannibalism.

Jennifer K Heppert1, Bob Goldstein1

  • 1Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Nature Cell Biology
|November 30, 2016
PubMed
Summary
This summary is machine-generated.

Neighboring cells consume protrusions from Caenorhabditis elegans germ cell precursors. This "intercellular cannibalism" may regulate the number of primordial germ cells.

More Related Videos

Manipulation of Ploidy in Caenorhabditis elegans
07:54

Manipulation of Ploidy in Caenorhabditis elegans

Published on: March 15, 2018

11.6K
Generating Chimeric Zebrafish Embryos by Transplantation
21:01

Generating Chimeric Zebrafish Embryos by Transplantation

Published on: July 17, 2009

21.9K

Related Experiment Videos

Last Updated: Mar 11, 2026

A Simple and Effective Transplantation Device for Zebrafish Embryos
06:59

A Simple and Effective Transplantation Device for Zebrafish Embryos

Published on: August 2, 2021

4.2K
Manipulation of Ploidy in Caenorhabditis elegans
07:54

Manipulation of Ploidy in Caenorhabditis elegans

Published on: March 15, 2018

11.6K
Generating Chimeric Zebrafish Embryos by Transplantation
21:01

Generating Chimeric Zebrafish Embryos by Transplantation

Published on: July 17, 2009

21.9K

Area of Science:

  • Developmental biology
  • Cell biology
  • Genetics

Background:

  • Early studies in the 1980s observed unusual lobes on Caenorhabditis elegans germ cell precursors.
  • The function and fate of these lobes remained unknown for many years.

Purpose of the Study:

  • To investigate the fate and significance of the protruding lobes from Caenorhabditis elegans germ cell precursors.
  • To understand the interaction between germ cell precursors and neighboring somatic cells.

Main Methods:

  • Utilized advanced microscopy techniques to observe cellular interactions in Caenorhabditis elegans.
  • Performed genetic analysis to identify the mechanisms underlying lobe removal.

Main Results:

  • Demonstrated that adjacent endodermal cells actively sever and digest these lobes.
  • Identified this process as a novel form of 'intercellular cannibalism'.

Conclusions:

  • Intercellular cannibalism by endodermal cells plays a crucial role in regulating Caenorhabditis elegans primordial germ cell populations.
  • This finding sheds new light on germ cell development and regulation in C. elegans.