Related Experiment Video
Updated: Mar 11, 2026
09:43
Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
Published on: January 14, 2014
8.5K
Concurrent Gliosarcoma and Choroid Plexus Carcinoma in a Cow
A Ortloff1, J Neumann1, O Illanes2
1Escuela de Medicina Veterinaria, Facultad de Recursos Naturales, Núcleo de Producción Alimentaria, Laboratorio de Anatomía Patológica, Universidad Católica de Temuco, Chile.
Journal of Comparative Pathology
|December 1, 2016
Summary
This study reports the rare simultaneous occurrence of two distinct primary brain tumors, gliosarcoma and choroid plexus carcinoma, in a cow. Gliosarcoma, a glioblastoma variant, is described in animals for the first time.
Area of Science:
- Veterinary Neurology
- Comparative Pathology
- Oncology
Background:
- Primary brain tumors are rare in animals, with multiple concurrent types being exceptionally uncommon.
- Gliosarcoma, a rare glioblastoma variant, has not been previously documented in veterinary literature.
Observation:
- An 8-year-old cow presented with a 2-month history of neurological disease.
- Microscopical and immunofluorescence evaluation revealed two distinct primary brain tumors.
Findings:
- Simultaneous diagnosis of gliosarcoma and choroid plexus carcinoma in the bovine brain.
- Gliosarcoma is characterized by malignant glial and mesenchymal cells.
Implications:
- This case expands the known spectrum of spontaneous brain tumors in cattle.
- Highlights the importance of thorough histopathological examination for diagnosing complex neurological conditions in animals.
- Provides a comparative oncology model for studying multiple primary brain tumors.
