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WormBase ParaSite - a comprehensive resource for helminth genomics.

Kevin L Howe1, Bruce J Bolt1, Myriam Shafie2

  • 1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

Molecular and Biochemical Parasitology
|December 1, 2016
PubMed
Summary

WormBase ParaSite offers a centralized resource for exploring over 100 parasitic worm genomes. This platform enhances helminth functional genomics research through integrated data and analysis tools.

Keywords:
Comparative genomicsEnsemblFunctional genomicsGenome browserHelminthsWormBase

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Area of Science:

  • Genomics
  • Parasitology
  • Bioinformatics

Background:

  • Increasing availability of parasitic worm genome sequences.
  • Growing research interest in helminth functional genomics.
  • Need for systematic data organization and analysis.

Purpose of the Study:

  • To present WormBase ParaSite, a portal for large-scale helminth genome interrogation.
  • To integrate and add value to genomic data from over 100 nematode and platyhelminth species.
  • To provide researchers with tools for exploring helminth genomic data.

Main Methods:

  • Development of the WormBase ParaSite web portal.
  • Integration of genomic data from over 100 species.
  • Systematic functional annotation, gene expression analysis, and comparative analysis.
  • Implementation of genome browsers, summary pages, search functions, and programmatic interfaces.

Main Results:

  • WormBase ParaSite integrates data from over 100 nematode and platyhelminth species.
  • The portal provides systematic functional annotation, gene expression, and comparative analyses.
  • Multiple data exploration tools are available, including genome browsers and search functionalities.
  • Programmatic interfaces and bulk downloads facilitate large-scale data access.

Conclusions:

  • WormBase ParaSite is a vital resource for researchers in helminth genomics.
  • The portal enhances the utility of parasitic worm genomic data.
  • It supports large-scale analysis and exploration of helminth genomes.