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XTalkDB: a database of signaling pathway crosstalk
Sarah A Sam1,2, Joelle Teel1, Allison N Tegge3,4
1Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA.
XTalkDB is a new database documenting signaling pathway crosstalk from scientific literature. It details molecular mediators and species, aiding systems biology research.
Area of Science:
- Systems biology
- Molecular biology
- Bioinformatics
Background:
- Signaling pathway crosstalk is crucial in systems biology.
- Existing literature lacks a centralized, explicit database for pathway crosstalk.
- Understanding crosstalk is vital for deciphering complex biological processes.
Purpose of the Study:
- To create a comprehensive database (XTalkDB) documenting specific signaling pathway crosstalk.
- To provide a resource for researchers studying molecular interactions between pathways.
- To facilitate systems biology research by organizing crosstalk information.
Main Methods:
- Curated data from over 1600 publications.
- Systematic identification and documentation of 650 pathway pairs.
- Development of a web interface for data retrieval.
Main Results:
- XTalkDB contains curated information on 650 pathway pairs.
- The database details molecular mediators (proteins, hormones, microRNAs) of crosstalk.
- Information on species and tissue context for each crosstalk interaction is provided.
Conclusions:
- XTalkDB addresses a critical gap in systems biology resources.
- The database offers a user-friendly platform for exploring pathway crosstalk.
- XTalkDB supports advanced research in molecular signaling and systems biology.
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