Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.1K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.1K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

16.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
16.4K
Genetic Screens02:46

Genetic Screens

5.8K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Harmonizing standards and resources for the medical genome.

Nature·2026
Same author

Novel Genetic Risk Loci for Pancreatic Ductal Adenocarcinoma Identified in a Genome-wide Study of African Ancestry Individuals.

medRxiv : the preprint server for health sciences·2026
Same author

Database resources of the National Center for Biotechnology Information in 2026.

Nucleic acids research·2025
Same author

Advancing the science of genomic learning healthcare systems.

Learning health systems·2025
Same author

Design and implementation of an action plan for justice, equity, diversity, and inclusion within the Clinical Genome Resource.

American journal of human genetics·2025
Same author

Genomic medicine year in review: 2024.

American journal of human genetics·2024

Related Experiment Video

Updated: Mar 11, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

5.4K

The dbGaP data browser: a new tool for browsing dbGaP controlled-access genomic data.

Kira M Wong1, Kristofor Langlais2, Geoffrey S Tobias3

  • 1National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20814, USA.

Nucleic Acids Research
|December 1, 2016
PubMed
Summary
This summary is machine-generated.

The new Genotypes and Phenotypes (dbGaP) Data Browser offers researchers view-only access to individual-level genomic and phenotypic data. This resource simplifies data access, reducing download requests and promoting responsible data sharing.

More Related Videos

A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers
08:12

A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers

Published on: July 18, 2025

763
Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance
04:58

Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance

Published on: December 13, 2024

4.4K

Related Experiment Videos

Last Updated: Mar 11, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

5.4K
A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers
08:12

A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers

Published on: July 18, 2025

763
Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance
04:58

Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance

Published on: December 13, 2024

4.4K

Area of Science:

  • Genomics
  • Bioinformatics
  • Data Science

Background:

  • Accessing controlled-access genomic data in dbGaP previously required lengthy data access requests and local data examination.
  • Existing resources offered only summary statistics or aggregate allele frequencies, not individual-level data.
  • The scientific community requested a resource for viewing dbGaP data without full download and review processes.

Purpose of the Study:

  • To develop a user-friendly, view-only resource for accessing dbGaP data.
  • To provide access to individual-level genotype, sequence, and phenotypic data.
  • To streamline the process of exploring controlled-access genomic datasets.

Main Methods:

  • Development of the dbGaP Data Browser interface.
  • Integration of summary-level and individual-level data from dbGaP.
  • Implementation of a simplified controlled-access mechanism for general research use (GRU) studies.

Main Results:

  • The dbGaP Data Browser provides researchers with direct, view-only access to dbGaP data.
  • The browser facilitates exploration of genotype, sequence, and phenotype data.
  • A simplified controlled-access process is now available for GRU studies.

Conclusions:

  • The dbGaP Data Browser serves as a valuable tool for researchers needing to explore genomic datasets.
  • This resource is expected to reduce unnecessary data download requests.
  • The tool supports responsible genomic data sharing while maintaining data security.