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Open Targets: a platform for therapeutic target identification and validation

Gautier Koscielny1,2, Peter An3,4, Denise Carvalho-Silva3,5

  • 1Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK gautier.x.koscielny@gsk.com.

Nucleic Acids Research
|December 1, 2016
PubMed

Insights

We developed a platform linking drug targets to diseases using genome-wide data. This tool aids researchers in identifying and prioritizing biological targets for further investigation and drug discovery.

Area of Science:

  • Genomics
  • Pharmacology
  • Bioinformatics

Background:

  • Identifying associations between drug targets and diseases is crucial for drug discovery.
  • Existing data sources are often fragmented, hindering comprehensive analysis.
  • Prioritizing biological targets requires robust evidence integration.

Purpose of the Study:

  • To design and develop a data integration and visualization platform.
  • To provide evidence linking known and potential drug targets with diseases.
  • To support the identification and prioritization of biological targets for follow-up studies.

Main Methods:

  • Integrated genome-wide data from diverse sources.
  • Developed a platform with target-centric and disease-centric workflows.
  • Enabled seamless transition between target- and disease-based analyses.

Main Results:

  • A comprehensive platform linking drug targets to diseases is now available.
  • The platform facilitates exploration of target-disease associations.
  • Genome-wide data integration supports evidence-based target identification.

Conclusions:

  • The Open Targets Validation Platform enhances drug target identification and prioritization.
  • Integrated data and flexible workflows streamline research.
  • Facilitates a deeper understanding of target-disease relationships for therapeutic development.

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