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Updated: Mar 11, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

The mouse Gene Expression Database (GXD): 2017 update.

Jacqueline H Finger¹, Constance M Smith¹, Terry F Hayamizu¹

¹The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

Nucleic Acids Research

|December 1, 2016

Summary

This summary is machine-generated.

The Gene Expression Database (GXD) provides comprehensive mouse developmental expression data from scientific literature and large projects. It integrates genetic and phenotypic information, offering over 1.5 million results and 300,000 images for advanced searching.

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Area of Science:

Developmental Biology
Genomics
Bioinformatics

Background:

The Gene Expression Database (GXD) is a vital resource for mouse developmental expression data.
It aggregates information from various experimental methods and sources, including scientific literature and large-scale projects.
Data encompasses both wild-type and mutant mouse models, integrating genetic and phenotypic information.

Purpose of the Study:

To provide an updated overview of the Gene Expression Database (GXD).
To highlight recent enhancements in data content, infrastructure, and search functionalities.
To emphasize GXD's role as a comprehensive resource for mouse developmental expression.

Main Methods:

Curation of scientific literature for expression data.
Integration of data from large-scale expression projects.
Collection of data from RNA in situ hybridization, immunohistochemistry, RT-PCR, northern blot, and western blot experiments.
Combination of expression data with genetic and phenotypic data from Mouse Genome Informatics (MGI).

Main Results:

GXD currently houses over 1.5 million expression results and more than 300,000 images.
Significant data additions and infrastructure enhancements have been implemented since 2014.
New search and display features, including a Mouse Developmental Anatomy Browser and interactive matrix views, have been introduced.

Conclusions:

GXD continues to be an extensive and well-curated resource for mouse developmental expression information.
Enhanced search and visualization tools improve accessibility and utility for researchers.
The database facilitates deeper understanding of gene function and developmental processes in mice.