Related Experiment Video
Updated: Mar 11, 2026
Transcranial Direct Current Stimulation and Simultaneous Functional Magnetic Resonance Imaging
Published on: April 27, 2014
Transcranial Direct Current Stimulation Potentiates Improvements in Functional Ability in Patients With Chronic
Krystian Figlewski1, Jakob Udby Blicher2, Jesper Mortensen2
1From the Hammel Neurorehabilitation Centre and University Research Clinic, Denmark (K.F., J.M., J.F.N., H.A.); Centre for Functionally Integrative Neuroscience, Aarhus University Hospital, Denmark (J.U.B.); and Department of Neurology, Aarhus University Hospital, Denmark (K.E.S., H.A.). kryfig@rm.dk.
Background And Purpose:
Transcranial direct current stimulation may enhance effect of rehabilitation in patients with chronic stroke. The objective was to evaluate the efficacy of anodal transcranial direct current stimulation combined with constraint-induced movement therapy of the paretic upper limb.
Methods:
A total of 44 patients with stroke were randomly allocated to receive 2 weeks of constraint-induced movement therapy with either anodal or sham transcranial direct current stimulation. The primary outcome measure, Wolf Motor Function Test, was assessed at baseline and after the intervention by blinded investigators.
Results:
Both groups improved significantly on all Wolf Motor Function Test scores. Group comparison showed improvement on Wolf Motor Function Test in the anodal group compared with the sham group.
Conclusions:
Anodal transcranial direct current stimulation combined with constraint-induced movement therapy resulted in improvement of functional ability of the paretic upper limb compared with constraint-induced movement therapy alone.
Clinical Trial Registration:
URL: http://www.clinicaltrials.gov. Unique identifier: NCT01983319.
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