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Related Experiment Video

Updated: Mar 11, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

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Vanishing Pituitary Macroadenoma: A Case Report.

Emily P Sieg1, Hayk Stepanyan2, Russell Payne1

  • 1Department of Neurosurgery, Penn State Hershey Medical Center.

Cureus
|December 1, 2016
PubMed
Summary

A non-functioning pituitary macroadenoma (NFPA) unexpectedly regressed before surgery. This case highlights spontaneous tumor resolution as a rare but possible outcome in pituitary macroadenoma management.

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Area of Science:

  • Endocrinology
  • Neurosurgery
  • Oncology

Background:

  • Pituitary macroadenomas are common suprasellar tumors, often causing visual disturbances (bitemporal hemianopsia) or endocrine dysfunction.
  • Symptomatic pituitary macroadenomas are typically treated with transsphenoidal resection.
  • Non-functioning pituitary macroadenomas (NFPAs) do not secrete hormones but can cause mass effect.

Observation:

  • A 55-year-old male presented with a diagnosed non-functioning pituitary macroadenoma.
  • The patient was scheduled for transsphenoidal hypophysectomy.
  • Pre-operative MRI revealed near-complete tumor regression, with only residual pituitary tissue remaining.

Findings:

  • The pituitary macroadenoma demonstrated significant spontaneous regression between diagnosis and planned surgical intervention.
Keywords:
adenomapituitary macroadenomaspontaneous regressionsuprasellar mass

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  • This regression occurred without any specific therapeutic intervention aimed at tumor shrinkage.

    • Implications:

    • Spontaneous regression of pituitary macroadenomas, though rare, should be considered in the differential diagnosis and management planning.
    • Further research into the mechanisms of spontaneous pituitary tumor regression may reveal novel therapeutic targets.
    • This case underscores the importance of serial imaging in monitoring pituitary macroadenomas, even when surgical intervention is planned.