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Hemoglobin Nouakchott [alpha 114(GH2)Pro----Leu]: a new hemoglobin variant displaying an unusual increase in
H Wajcman1, J Delaunay, A Francina
1INSERM U299, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.
Biochimica Et Biophysica Acta
|September 14, 1989
Abstract:
The most striking fact in Hb Nouakchott [alpha 114(GH2)Pro----Leu] is the highly increased hydrophobicity of the abnormal chain. In comparison to other variants carrying the same amino-acid substitution, but at another position, the involvement of the environmental domains in the expression of the hydrophobicity is shown. Even though the substitution concerned a proline residue, it was without consequences on the oxygen binding and the stability of the molecule.