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Microorganisms in Medicine and Therapeutics01:29

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Current Perspectives on Antihypertensive Probiotics.

Eric Banan-Mwine Daliri1, Byong H Lee1,2, Deog H Oh3

  • 1Department of Food Science and Biotechnology, Kangwon National University, Chuncheon, 200-701, South Korea.

Probiotics and Antimicrobial Proteins
|December 1, 2016
PubMed
Summary

Probiotics and fermented foods can help manage hypertension by improving gut health. These interventions lower blood pressure through various mechanisms, contributing to better cardiovascular health.

Keywords:
CholesterolHypertensionInflammationMicrobiotaRenin-angiotensin system

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Area of Science:

  • Microbiology
  • Cardiovascular Health
  • Gastroenterology

Background:

  • Hypertension is a significant cardiovascular disease risk factor.
  • Gut microbiota influences host metabolism, immunity, and physiology.
  • Dietary interventions targeting gut microbiota are crucial for metabolic diseases.

Purpose of the Study:

  • To review the antihypertensive effects of probiotics and fermented products.
  • To explore mechanisms including cholesterol reduction, anti-inflammation, and ACE inhibition.
  • To discuss the potential of recombinant probiotics in blood pressure management.

Main Methods:

  • Literature review of studies on probiotics, fermented products, and hypertension.
  • Analysis of mechanisms: nitric oxide suppression, reactive oxygen species reduction, calcium absorption enhancement.
  • Examination of effects on hypercholesterolemia, inflammation, and renin-angiotensin system.

Main Results:

  • Probiotics and fermented products demonstrate antihypertensive properties.
  • Mechanisms include modulation of inflammatory pathways and angiotensin-converting enzyme activity.
  • Enhanced dietary calcium absorption and reduced oxidative stress contribute to blood pressure regulation.

Conclusions:

  • Probiotics and their fermented products offer a promising dietary strategy for hypertension management.
  • Targeting gut microbiota may help control blood pressure and reduce cardiovascular risk.
  • Recombinant probiotics present a novel approach for further blood pressure reduction.