Related Experiment Video
Updated: Mar 11, 2026
07:12
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
5.1K
[Symptomatic and asymptomatic primary hyperparathyroidism in outpatient care - current issues]
Vnitrni Lekarstvi
|December 1, 2016
Summary
Primary hyperparathyroidism often presents with normal calcium levels, but a significant portion can develop hypercalcemia over time. Early detection and monitoring are crucial for managing this biphasic disease in outpatient settings.
Area of Science:
- Endocrinology
- Internal Medicine
- Nephrology
Background:
- Primary hyperparathyroidism (PHPT) is a common endocrine disorder.
- It is characterized by excessive secretion of parathyroid hormone (PTH).
- PHPT can present with hypercalcemia or normocalcemia, impacting diagnostic and therapeutic strategies.
Purpose of the Study:
- To evaluate diagnostic and therapeutic approaches for primary hyperparathyroidism in outpatient care.
- To analyze the progression from normocalcemic to hypercalcemic PHPT.
- To compare outcomes between surgical and pharmacological interventions.
Main Methods:
- A retrospective cohort study of 218 patients with PHPT from 2008-2013.
- Exclusion of secondary hyperparathyroidism, hypovitaminosis D, and renal insufficiency.
- Ultrasound and scintigraphy for diagnostic imaging, particularly for surgical candidates.
Main Results:
- 14% of patients presented with hypercalcemia, while 86% had normocalcemia.
- One-fifth of normocalcemic patients developed hypercalcemia within two years.
- Parathyroid adenoma was successfully removed in 97% of operated hypercalcemic patients and 40% of operated normocalcemic patients.
Conclusions:
- Primary hyperparathyroidism is a biphasic disease with an often asymptomatic normocalcemic phase.
- Normocalcemic PHPT patients may already have severe complications.
- Further research is needed to guide monitoring and treatment initiation for normocalcemic PHPT.
Related Concept Videos
01:11Secondary Healthcare System
2.1K
Secondary healthcare is offered by a specialist, generally in hospitals or clinics for patients referred by primary healthcare providers. It occurs when a person has an illness or injury that requires specific medical care. Secondary care is often referred to as acute care. Secondary care can range from uncomplicated care to repair a minor laceration or treat a strep throat infection to more complicated emergent care, such as treating a head injury sustained in an automobile accident. Whatever...
2.1K
01:30Primary Healthcare Services
2.6K
Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
In 1978, international leaders convened in Alma-Ata, Kazakhstan, for what would be a pivotal event in global health. The Alma-Ata Declaration was the first to call...
In 1978, international leaders convened in Alma-Ata, Kazakhstan, for what would be a pivotal event in global health. The Alma-Ata Declaration was the first to call...
2.6K
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
690
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
690
01:28Chronic Kidney Disease III: Interprofessional Care
565
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
565
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
569
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
569
01:30Preventive Healthcare Services
2.3K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
2.3K