Selecting heart failure patients for metabolic interventions.
Harmen G Booij1, Anne M Koning1, Harry van Goor1
1a University Medical Center Groningen , University of Groningen , Groningen , Netherlands.
Expert Review of Molecular Diagnostics
|December 1, 2016
Summary
Identifying specific metabolic dysfunction in heart failure (HF) patients is key to developing effective therapies. Precision medicine approaches using biomarkers and imaging can target these mechanisms for better treatment outcomes.
Area of Science:
- Cardiology
- Metabolic Medicine
- Biochemistry
Background:
- Heart failure (HF) presents a significant global health challenge with limited therapeutic translation.
- Despite decades of research, metabolic dysfunction in HF remains poorly understood and untargeted.
- Variable metabolic contributions to HF hinder effective treatment development.
Purpose of the Study:
- To review maladaptive metabolic changes in failing hearts.
- To compare biomarkers and molecular imaging for detecting metabolic dysfunction in HF.
- To propose patient selection strategies for targeted metabolic interventions.
Main Methods:
- Literature evaluation of metabolic perturbations in HF.
- Comparison of diagnostic utility for biomarkers and molecular imaging.
- Framework development for patient stratification in metabolic HF therapy.
Main Results:
- Failing hearts exhibit metabolic inflexibility, oxidative stress, and energy depletion.
- Biomarkers and molecular imaging show potential for quantifying metabolic dysfunction.
- Patient selection is crucial for successful metabolic intervention in HF.
Conclusions:
- Metabolic dysfunction represents a promising therapeutic target for HF.
- Precise patient selection using advanced imaging and biomarkers is essential.
- Translating HF metabolic research into clinical practice requires targeted approaches.
Keywords:
Biomarkersheart failuremagnetic resonance spectroscopymetabolic dysfunctionoxidative stresspositron emission tomographyMore Related Videos
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