Exploring the activity of a polyazine bridged Ru(ii)-Pt(ii) supramolecule in F98 rat malignant glioma cells
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Jie Zhu1, José Á Rodríguez-Corrales1, Reece Prussin2
1Department of Chemistry, Virginia Tech., Blacksburg, Virginia 24061-0212, USA.
Abstract:
The mixed-metal supramolecular complex, [(Ph2phen)2Ru(dpp)PtCl2]2+, displays significant DNA modification, cell growth inhibition, and toxicity towards F98 malignant glioma cells following visible light irradiation. The design of this complex affords superior cellular uptake and antiproliferative activity compared to the classic chemotherapeutic agent, cisplatin.
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