Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Analytical solution of the radiative transfer equation of light radiance in a turbid slab with an inner-medium source under the P3-1D approximation.

Optics express·2026

Same author

De Novo Design of Near-Infrared Fluorescence-Activating Proteins.

Journal of the American Chemical Society·2026

Same author

Two-dimensional HRS condensates drive the assembly of flat clathrin lattices on endosomes.

Nature communications·2026

Same author

Ion-Pair Breakers and Anionic Brønsted Acids for Helmholtz-Layer Catalysis with External Electric Fields in Microfluidic Capacitors.

JACS Au·2026

Same author

Fluorescence lifetime estimation: A practical approach using Flipper-TR FLIM.

Methods in enzymology·2026

Same author

Flipper dendrimers.

Chemical science·2026

Same journal

A one-step immunoassay of Tau protein based on flow cytometric counting of target-induced nanoaggregates.

Chemical communications (Cambridge, England)·2026

Same journal

Decarboxylative alkylation of unactivated olefins <i>via</i> photoinduced Fe-LMCT: access to alkylated dihydropyrazoles/tetrahydropyridazines.

Chemical communications (Cambridge, England)·2026

Same journal

MOF-ionic liquid engineered polymer electrolyte for advanced solid-state sodium metal batteries.

Chemical communications (Cambridge, England)·2026

Same journal

Chemically-fueled transient peptide hydrogel enabling programmable time-gated functions.

Chemical communications (Cambridge, England)·2026

Same journal

The first structurally characterized coordination compounds with homocysteine.

Chemical communications (Cambridge, England)·2026

Same journal

Bimetallic Bi-In interfaces on micropyramidal silicon for efficient solar-driven CO<sub>2</sub>-to-formate conversion.

Chemical communications (Cambridge, England)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 11, 2026

Multifunctional, Micropipette-based Method for Incorporation And Stimulation of Bacterial Mechanosensitive Ion Channels in Droplet Interface Bilayers

Multifunctional, Micropipette-based Method for Incorporation And Stimulation of Bacterial Mechanosensitive Ion Channels in Droplet Interface Bilayers

Published on: November 19, 2015

Headgroup engineering in mechanosensitive membrane probes.

Saeideh Soleimanpour¹, Adai Colom¹, Emmanuel Derivery¹

¹NCCR Chemical Biology, School of Chemistry and Biochemistry, University of Geneva, Geneva, Switzerland. stefan.matile@unige.ch.

Chemical Communications (Cambridge, England)

|December 1, 2016

Summary

This summary is machine-generated.

Researchers engineered stable, versatile push-pull flipper probes for biological applications. These probes provide new insights into how chalcogen bonds affect mechanophore degradation and fluorescence.

More Related Videos

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients

Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients

Published on: July 16, 2018

Related Experiment Videos

Last Updated: Mar 11, 2026

Multifunctional, Micropipette-based Method for Incorporation And Stimulation of Bacterial Mechanosensitive Ion Channels in Droplet Interface Bilayers

Multifunctional, Micropipette-based Method for Incorporation And Stimulation of Bacterial Mechanosensitive Ion Channels in Droplet Interface Bilayers

Published on: November 19, 2015

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients

Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients

Published on: July 16, 2018

Area of Science:

Chemical Biology
Materials Science

Background:

Mechanophores are molecules that change properties upon mechanical force.
Push-pull systems are crucial for designing responsive materials.
Flipper probes offer unique conformational flexibility.

Purpose of the Study:

To develop novel, stable, and adaptable push-pull flipper probes for biological applications.
To investigate the role of chalcogen bonds in mechanophore degradation.
To understand fluorescence enhancement mechanisms in these probes.

Main Methods:

Systematic headgroup engineering of push-pull flipper probes.
Characterization of probe stability, accessibility, and modifiability.
Investigation of chalcogen-bond mediated degradation pathways.
Analysis of fluorescence properties under mechanical stress.

Main Results:

Successfully synthesized planarizable push-pull flipper probes suitable for biological use.
Demonstrated the probes' stability, accessibility, and ease of modification.
Uncovered significant insights into chalcogen-bond mediated mechanophore degradation.
Observed fluorescence enhancement correlated with probe structure and mechanical input.

Conclusions:

Systematic headgroup engineering is effective for creating advanced flipper probes.
These probes are valuable tools for studying mechanophore dynamics in biological systems.
Chalcogen bonds play a critical role in the mechanical response of these novel probes.